Using Langerin-eGFP-DTR mice, we analyzed the role of LCs in the mechanisms of tolerance induction by EPIT in vivo. Only LCs induced LAP + cells and CD62L + Tregs. These 2 populations induced Foxp3 expression in CD4 + cells in vitro. Using OVA-sensitized BALB/c mice, we demonstrated that the application of a patch containing OVA-A647 to the skin resulted in allergen uptake by Langerhans cells (LCs) and CD11b + dermal cDC2 and subsequent migration into skin draining lymph nodes. The role of different populations of skin DCs in tolerance induction remains to be elucidated. Among immune cells in the skin, dendritic cells are key players in antigen-specific immune activation or regulation. Epicutaneous immunotherapy (EPIT) has been proposed as an attractive strategy to actively treat food allergy and has been shown to induce tolerance in sensitized mice through the induction of Foxp3 + regulatory T cells (Tregs), especially CD62L + Tregs. The skin is a major immunologic organ that may induce protection, sensitization or tolerance. 3DBV Technologies, New York, NY, United States.2Department of Pediatric Gastroenterology Hepatology and Nutrition, Hôpital Necker Enfants Malades, Paris, France.Paired perfectly with Black Crow Climbing skins From Pomoca.Vincent Dioszeghy 1 *, Lucie Mondoulet 1, Leo Laoubi 1, Véronique Dhelft 1, Camille Plaquet 1, Adeline Bouzereau 1, Christophe Dupont 2 and Hugh Sampson 3 Mountaineering missions, European touring vacations (Haute Route anyone?), or simply those who prefer a narrow touring ski will really dig the Ova.
Spring time hop turns in tight chutes that open up into GS turns on a wide apron are right in the Ova's wheel house. A cap construction eliminates excess weight from side wall material and thinner edges round out the package. The wood core is now solid Paulownia, which has become the industry standard for lightweight skis. The weight reduction comes from a new core, thinner edges and cap construction. A tight 17m turn radius, subtle tip rocker, and slight early rise allow the ski to still pivot quickly in tight chutes or trees. But don't let the weight fool you, this ski is still for skiing down.īuilt on the chassis of the on-piste carving, firm snow dominating Vertis, the Ova Freebird has the shape for stability in technical terrain. New this year, is the super light weight construction previously found only in the Vastus Freebird. The Crows found however, that once people chose a ski under 90mm under foot, the intention is for long distance or speed mountaineering missions where weight is paramount. The Black Crows Freebird line in general is light, but not ultralight, focusing on downhill performance and limited chatter.
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